Question
Cross Section of Arterioile shows the following histology. Diagnosis ?
A. Atherosclerosis
B. Medial calcific sclerosis
C. Hyaline arteriosclerosis
D. Hyperplastic arteriosclerosis
Show Answer
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Correct Answer » D
Explanation
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The Histology Shows Onion Peel Appearance
| Hyperplastic arteriolosclerosis: Associated with malignant hypertension. It is a concentric, cellular thickening (i.e., onion-skinning) of the wall associated with fibrinoid necrosis.
This is a type of arteriolosclerosis involving a narrowed lumen. The term “onion-skin” is sometimes used to describe this form of blood vessel with thickened concentric smooth muscle cell layer and thickened, duplicated basement membrane. In malignant hypertension. these hyperplastic changes are often accompanied by fibrinoid necrosis of the arterial intima and media. These changes are most prominent in the kidney and can lead to ischemia and acute kidney failure.
Atherosclerosis: Grossly recognizable atherosclerosis begins as a fatty streak and progresses to a fibroatheroma.
Mönckeberg medial calcification: A condition of little clinical significance because the changes are nonstenotic. It is characterized by medial calcification (“pipestem rigidity”) of the muscular arteries (often radial and ulnar arteries) in elderly men.
Hyaline arteriolosclerosis: Associated with benign hypertension. It is eosinophilic, acellular thickening of the wall of arterioles.
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