Biochemistry Basics – 14997

Question

ECG of a young person admitted with diarrhea shows bradycardia, prolonged PR and flat T waves.
 
Assertion: Cholera toxin prevents the absorption of salts from the intestine leading to watery diarrhea and loss of water from the body.
 
Reason: The toxin binds to ganglioside on intestinal mucosal cells, which ribosylates the alpha subunit of Gi protein and prevents the Gi-GDP complex from interacting with the activated receptor.
A. Both Assertion and Reason are true, and Reason is the correct explanation for Assertion

B. Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion

C. Assertion is true, but Reason is false

D. Assertion is false, but Reason is true

 

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