Question
The following methods can be used to detect the point mutation in the beta ((3)-globin gene that causes this type of anemia, except
A. Polymerase chain reaction with allele-specific oligonucleotide hybridization
B. Southern blot analysis
C. DNA sequencing
D. Northern blot analysis
Show Answer
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Correct Answer ยป D
Explanation
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These cells are sickel cell
D i.e. Northern blot analysis
Definitive diagnosis of a point mutation in the beta globin gene requires DNA analysis. Northern blot test is a technique used to study the RNA, rather than DNA and hence is the answer of exclusion.
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