Which of the following drug is contraindicated in a patient suffering from a disorder as shown in the picture below?
The patient is suffering from myasthenia gravis.
- Myasthenia gravis is an autoimmune disorder of neuromuscular transmission involving the production of autoantibodies directed against the nicotinic AChR.
- Drugs that impair neuromuscular junction transmission should be avoided in a patient of Myasthenia gravis as they may increase weakness.
- Curare(Neuro-muscular Blocking Agent)
- D-penicillamine Botulinum toxin
- Interferon alpha
- Antibiotics — aminoglycosides (gentamycin, kanamycin, neomycin, streptomycin, tobramycine); macrolides (erythromycin, azithromycin, telithromycin,) Fluoroquinolones (ciprofloxacin, norfloxacin, levofloxacin);
- Quinine, quinidine, procainamide,
- Magnesium salts, iv magnesium replacement.
Caution- may exacerbate weakness in some myasthenics
- Calcium channel blockers
- Beta blockers
- Iodinated contrast agents