Question
Peripheral neuritis due to the drug shown in the picture below is due to formation of which complex ?
A. Hydrazone complex.
B. Isobutane complex.
C. Isoazoic complex.
D. Hydralazine complex.
Show Answer
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Correct Answer » A
Explanation
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Ans:A. Hydrazone complex.
Peripheral neuritis due to isoniazid is due to formation of Hydrazone complex.
- Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits gneration of pyridoxal phosphate.
- Isoniazid also combines with pyridoxal phosphate to interfere with its coenzyme function. Due to formation of hydrazones, the renal excretion of pyridoxine compounds is increased.
Thus, isoniazid therapy produces a pyridoxine deficiency state.
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