Identify the virus whose photomicrograph is given in the image that enters the epithelial cells and B cells through CD21 receptors. and whose transmission occurs by the oral transfer of saliva and genital secretions.
Marked cells are Atypical lymphocytes
Epstein – Barr Virus (EBV)
- The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known viruses in the herpes family.
- The virus enter the pharyngeal epithelial cells and B cells through (CR 2 / or CD21) receptors.
- Memory B Cells are the reservoir of EBV.
- Infection with EBV occurs by the oral transfer of saliva and genital secretions.
- It is best known as the cause of infectious mononucleosis (glandular fever).
- The 3 classic criteria for laboratory confirmation of acute infectious mononucleosis include (1) lymphocytosis, (2) the presence of at least 10% atypical lymphocytes on peripheral smear, and (3) a positive serologic test result for Epstein-Barr virus (EBV).
- The atypical lymphocytes are larger, have a lower nuclear-to-cytoplasmic ratio, and have a nucleus that is less dense than that of normal lymphocytes.
- It is also associated with particular forms of cancer, such as Hodgkin’s lymphoma, Burkitt’s lymphoma, gastric cancer, nasopharyngeal carcinoma, and conditions associated with human immunodeficiency virus (HIV), such as hairy leukoplakia and central nervous system lymphomas.