Question
Drug effective for most parasites as shown in the picture below is ?
A. Praziquental.
B. Pirenzipine.
C. Niclosamids.
D. Pyrantel palmoate.
Show Answer
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Correct Answer » A
Explanation
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The parasite shown in the picture above represents trematode.
Drug effective for most trematodes is Praziquantal.
Praziquental
- Praziquantal is the DOC for treatment of all trematodes and cestodes except for fasciola hepatica (DOC bithionol) and hydatid disease (DOC albendazole), Neurocysticercosis (DOC is albendazole).
- It acts by causing leakage of intracellular calcium from the membrane —9 contracture & paralysis.
- At relatively higher concentrations, it causes vacuolization of the tegument and release of the contents of tapeworms and flukes followed by their destruction by the host -3 this action appear to be more important in case of schistosomes and flukes.
- Despite systemic absorption praziquantel exhibits no systemic toxicity.
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