Image Based Question-66300

A child presents with this condition all over his body, including the buccal mucosa, lips, palms, soles, and skin not exposed to sun. Which of the following additional findings would most likely be present?

A. Colonic polyps.

B. Desmoid tumors.

C. Epidermoid cysts.

D. Osteomas of the jaw.

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Correct Answer » A Explanation

This condition is Feckels

The widespread “freckles” (spots of melanin pigmentation) described in this case are associated with hamartomatous colonic polyps in Peutz-Jeghers syndrome.

The polyps in Peutz-Jeghers syndrome do not progress to colon cancer.

Interestingly, Peutz-Jeghers syndrome is associated with an increased potential to develop carcinomas of the pancreas, breast, ovary, uterus, and lung.

All of the other features listed are components of Gardner’s syndrome, a variant of familial adenomatous polyposis syndrome, which carries a greatly increased risk of colon cancer.