A. Down’s syndrome.
B. Patau syndrome.
C. Noonan syndrome.
D. Turner’s syndrome.
Patau syndrome is the least common and most severe of the viable autosomal trisomies.
Median survival is fewer than 3 days.
First identified as a cytogenetic syndrome in 1960, Patau syndrome is caused by an extra copy of chromosome 13, a medium-length acrocentric chromosome.
- Many of the clinical features widely vary; however, severe mental deficiency is a consistent feature in children born with Patau syndrome.
- Holoprosencephaly, polydactyly, flexion of the fingers, rocker-bottom feet, facial clefting, neural tube defects and heart defects are also frequent clinical features.
- Patau syndrome is generally recognized at birth by the presence of structural birth defects and poor neurologic performance.