Question
Which among the following is the most commonly used biomarker for reserve of organ as marked in the picture below ?
A. LH.
B. FSH.
C. LH: FSH ratio.
D. Estradiol levels.
Show Answer
Correct Answer » B
Explanation
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The structure marked in the picture above represents ovary.
The primary function of the female ovary is the production of a mature and viable oocyte capable of fertilization and subsequent embryo development and implantation. At birth, the ovary contains a finite number of oocytes available for folliculogenesis.
This finite number of available oocytes is termed “the ovarian reserve”. The determination of ovarian reserve is important in the assessment and treatment of infertility. As the ovary ages, the ovarian reserve will decline.
The most commonly used biomarker assay to assess ovarian reserve is the measurement of follicle stimulating hormone (FSH) on day 3 of the menstrual cycle.
However, anti-müllerian hormone and inhibin-B are other biomarkers of ovarian reserve that are gaining in popularity since they provide direct determination of ovarian status, whereas day 3 FSH is an indirect measurement.
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