A. Open neural tube defects.
B. Open neural tube defects.
C. Down syndrome.
D. Edward syndrome.
The fluid marked by a red arrow in the picture above represents amniotic fluid.
Increase acetylcholinestrase in amniotic fluid indicates Open Neural Tube Defect.
Prenatal diagnosis of neural tube defect
- In intra embryonic life, neural tube is open at both end and freely communicate with amniotic cavity.
- Failure of closure of neural tube results in persistant of this communication.
- This allows excretion of following fetal substances into amniotic cavity ‑
- Alpha – fetoprotein
- These serve as biochemical marmkers for NTDs for prenatal diagnosis.