Question
Increase acetylcholinestrase in the fluid marked by a red arrowm in the picture below indicates ?
A. Open neural tube defects.
B. Open neural tube defects.
C. Down syndrome.
D. Edward syndrome.
Show Answer
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Correct Answer » A
Explanation
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The fluid marked by a red arrow in the picture above represents amniotic fluid.
Increase acetylcholinestrase in amniotic fluid indicates Open Neural Tube Defect.
Prenatal diagnosis of neural tube defect
- In intra embryonic life, neural tube is open at both end and freely communicate with amniotic cavity.
- Failure of closure of neural tube results in persistant of this communication.
- This allows excretion of following fetal substances into amniotic cavity ‑
- Alpha – fetoprotein
- Acetykholinesterase
- These serve as biochemical marmkers for NTDs for prenatal diagnosis.
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