Alpha thallasemia is shown in the image.
C:Alpha thalasemia minor,Asymptomatic,Mild hemolytic Anemia
D:Hb H disease,Hemolytic and microcytic Anemia,Splenomegaly
E:Hydrops fetalis,Incompatible with life.
- These are defects in which the synthesis of α-globin chains is decreased or absent, typically as a result of deletional mutations.
- Because each individual’s genome contains four copies of the α-globin gene (two on each chromosome 16), there are several levels of α-globin chain deficiencies .