Question
In the following type of hemoglobinopathy in globin chain defect as shown in the image,the disease incompatible with life is?
Show Answer
Correct Answer » D
Explanation
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Ans:D. E.
Alpha thallasemia is shown in the image.
A:Normal
B:Carrier,Asymptomatic,No abnormalities
C:Alpha thalasemia minor,Asymptomatic,Mild hemolytic Anemia
D:Hb H disease,Hemolytic and microcytic Anemia,Splenomegaly
E:Hydrops fetalis,Incompatible with life.
Alpha thalassemias
- These are defects in which the synthesis of α-globin chains is decreased or absent, typically as a result of deletional mutations.
- Because each individual’s genome contains four copies of the α-globin gene (two on each chromosome 16), there are several levels of α-globin chain deficiencies .
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