Image Based Question – 69885

In the following type of hemoglobinopathy in globin chain defect as shown in the image,the disease incompatible with life is?

A. A.

B. B.

C. C.

D. E.

Show Answer

Correct Answer » D Explanation

Ans:D. E.

Alpha thallasemia is shown in the image.

A:Normal

B:Carrier,Asymptomatic,No abnormalities

C:Alpha thalasemia minor,Asymptomatic,Mild hemolytic Anemia

D:Hb H disease,Hemolytic and microcytic Anemia,Splenomegaly

E:Hydrops fetalis,Incompatible with life.

Alpha thalassemias

• These are defects in which the synthesis of α-globin chains is decreased or absent, typically as a result of deletional mutations.

• Because each individual’s genome contains four copies of the α-globin gene (two on each chromosome 16), there are several levels of α-globin chain deficiencies .