Image Based Question – 69968

A 16 year old boy presented with recurrent episodes of profuse nasal bleeding unilaterally.On examination,there is a mass seen in the nasal cavity.Histopathological examination shows the following features.What can be the most probable diagnosis?

A. Nasal Squamous Cell Carcinoma

B. Inflammatory Nasal Polyp

C. Inverted Papilloma

D. Nasopharyngeal Angiofibroma

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Correct Answer » D Explanation

Ans:D. Nasopharyngeal Angiofibroma.

Image shows:Angiofibroma nose. There is admixture of thin-walled blood vessels and spindled stroma. The blood vessels are variable-sized,some having incomplete muscle coat and there is absence of elastic tissue. The stroma has stellate fibroblasts and mast cells.

NASOPHARYNGEAL ANGIOFIBROMA.

• This is a peculiar tumour that occurs exclusively in adolescent males (10-20 years of age) suggesting the role of testosterone hormone in its production.

• Microscopically, the tumour is composed of 2 components as the name suggests—numerous small endothelium lined vascular spaces and the stromal cells which are myofibroblasts .

• The androgen-dependence of the tumour is confirmed by demonstration by immunostaining for androgen receptors in 75% cases.