Identify the below given image of a pathology affecting Arterial wall.
A. Hyaline Arteriosclerosis
C. Hyperplastic Arteriosclerosis
D. Senile Arteriosclerosis
Ans:C. Hyperplastic Arteriosclerosis
- The hyperplastic or proliferative type of arteriolosclerosis is a characteristic lesion of malignant hypertension; other causes include haemolytic-uraemic syndrome, scleroderma and toxaemia of pregnancy.
- The morphologic changes affect mainly the intima, especially of the interlobular arteries in the kidneys. Three types of intimal thickening may occur.
- Onion-skin lesion consists of loosely-placed concentric layers of hyperplastic intimal smooth muscle cells like the bulb of an onion. The basement membrane is also thickened and reduplicated.
- Mucinous intimal thickening is the deposition of amorphous ground substance, probably proteoglycans, with scanty cells.
- Fibrous intimal thickening is less common and consists of bundles of collagen, elastic fibres and hyaline deposits in the intima.
Severe intimal sclerosis results in narrowed or obliterated lumen. With time, the lesions become more and more fibrotic.