A patient presented with hesitancy, urgency, nocturia, and poor urinary stream.Prostate shows the following features.Regarding this pathology,which zone of prostate is affected?
A. Central Zone.
B. Periurethral Zone.
C. Peripheral Zone.
D. Transitional Zone.
Ans:B. Periurethral Zone.
- First:Nodular prostatic hyperplasia. Well-defined nodules compress the urethra into a slitlike lumen.
- Second:Low-power photomicrograph demonstrates a well-demarcated nodule at the right of the field, with a portion of urethra seen to the left. In other cases of nodular hyperplasia, the nodularity is caused predominantly by stromal, rather than glandular, proliferation.
- Third: Higher-power photomicrograph demonstrates the morphology of the hyperplastic glands, which are large, with papillary infolding
Benign Prostatic Hyperplasia(Nodular Hyperplasia)
- BPH is characterized by proliferation of benign stromal and glandular elements. DHT, an androgen derived from testosterone, is the major hormonal stimulus for proliferation.
- BPH most commonly affects the inner periuretheral zone of the prostate, producing nodules that compress the prostatic urethra.
- On microscopic examination, the nodules exhibit variable proportions of stroma and glands.
- Hyperplastic glands are lined by two cell layers: an inner columnar layer and an outer layer composed of flattened basal cells.
- Clinical symptoms and signs are reported by 10% of affected patients and include hesitancy, urgency, nocturia, and poor urinary stream. Chronic obstruction predisposes to recurrent urinary tract infections.Acute urinary obstruction may occur.