B. S- 100
C. HMB 45
D. Neuron specific enolase
Paget’s Disease of the Nipple is shown in the image.
PAGET’S DISEASE OF THE NIPPLE
Paget’s disease of the nipple is a superficial manifestation of an underlying breast carcinoma.
In most cases tumor cells have spread to the skin of the nipple and areola from underlying invasive ductal carcinoma or ductal carcinoma in situ.
- Presents as an eczema-like condition of the nipple and areola, which persists despite local treatment
- Eczema begin on the areola: Paget’s disease originates on the nipple and secondarily involves the areola
- The nipple is eroded slowly and eventually disappears
- Histology: Paget cells – large, ovoid vacuolated cells which do not invade the dermal basement membrane -therefore categorized as carcinoma in situ
- May be accompanied by a palpable mass in just over 50% of patients
- May be confused with superficial spreading melanoma
- Melanoma: S-100 antigen immunostaining: melanoma
- Paget’s disease: carcino embryonic antigen immunostaining