Question
Translocation seen in Ewing’s sarcoma is:
A. t(8,11)
B. t(11,22)
C. t(11,18)
D. t(14,18)
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Correct Answer » B
Explanation
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Ans: B. t(11,22)
Genetic exchange between chromosomes can cause cells to become cancerous. Most cases of Ewing’s sarcoma (85%) are the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.
Other translocations are at t(21;22) and t(7;22).
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