Etiology of depression

Etiology of depression

Biological Factors-

  • Neurotransmitter [ ↓ Levels of Serotonin & NE and dopamine in some cases]
  • Hormonal Disturbances [ Elevated activity in Hypothalamic-pituitary axis, Hypothyroidism
  • Neuroanatomical – ↓ activity in dorsolateral prefrontal cortex and ↑ in amygdala [Limbic system]

Genetic Factors-

  • CERB 1 on Chromosome 2 [cAMP response element binding protein]
  • Serotonin transporter gene

Psychological Factors-

Cognitive Theory [Aaron Beck] -Idea of worthlessness, Idea of Helplessness, Idea of hopelessness

Learned Helplessness – Repeated adverse events pt. believes that he has no control

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