Hepatoblastoma

Hepatoblastoma

Q. 1 Alpha feto protein is elevated in what percentage of children with hepatoblastoma:

 A 10%

 B

50%

 C

90%

 D

100%

Q. 1

Alpha feto protein is elevated in what percentage of children with hepatoblastoma:

 A

10%

 B

50%

 C

90%

 D

100%

Ans. C

Explanation:

Most liver function test results are normal.

Alpha-fetoprotein levels are increased in 90% of children with hepatoblastomas but are elevated much less commonly in children with other liver malignancies.
               
Ref: Schwartz’s principle of surgery 9th edition, chapter 39.

 


Q. 2 Definite markers for hepatoblastoma is-

 A

 LDH

 B

Alpha-fetoprotein (AFP)

 C

hCG

 D

Alkaline phosphatase

Ans. B

Explanation:

Ans. is ‘b’ i.e., Alpha – fetoprotein (AFP)

Hepatoblastoma

  • Hepatoblastoma is the most common primary hepatic tumor of childhood. Rare cases of adult hepatoblastoma have been reported, but overall, the median age of presentation is 18 months, & almost all cases occur before the age of 3 years.

o Recently it has been associated with familial polyposis syndrome.

o Most often, this tumor presents as an asymptomatic mass.

o It arise from right lobe 3 times more than left.

o Serum AFP is elevated in 85-90% of patients and can serve as a useful marker for therapeutic response.



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