Hepatoblastoma
Q. 1 Alpha feto protein is elevated in what percentage of children with hepatoblastoma:
| A | 10% | |
| B |
50% |
|
| C |
90% |
|
| D |
100% |
Q. 1
Alpha feto protein is elevated in what percentage of children with hepatoblastoma:
| A |
10% |
|
| B |
50% |
|
| C |
90% |
|
| D |
100% |
Ans.
C
B
Explanation:
Ref: Schwartz’s principle of surgery 9th edition, chapter 39.
Most liver function test results are normal.
Alpha-fetoprotein levels are increased in 90% of children with hepatoblastomas but are elevated much less commonly in children with other liver malignancies.
Ref: Schwartz’s principle of surgery 9th edition, chapter 39.
Q. 2 Definite markers for hepatoblastoma is-
| A |
LDH |
|
| B |
Alpha-fetoprotein (AFP) |
|
| C |
hCG |
|
| D |
Alkaline phosphatase |
Ans.
Explanation:
Ans. is ‘b’ i.e., Alpha – fetoprotein (AFP)
Hepatoblastoma
- Hepatoblastoma is the most common primary hepatic tumor of childhood. Rare cases of adult hepatoblastoma have been reported, but overall, the median age of presentation is 18 months, & almost all cases occur before the age of 3 years.
o Recently it has been associated with familial polyposis syndrome.
o Most often, this tumor presents as an asymptomatic mass.
o It arise from right lobe 3 times more than left.
o Serum AFP is elevated in 85-90% of patients and can serve as a useful marker for therapeutic response.
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