- A self-limited disorder primarily of teenagers and young adults
- The earliest feature is an increased rate of sebum secretion, making the skin look greasy (seborrhoea)
- A disorder in which hair follicles develop obstructing horny plugs (comedones).
- Small pseudocysts, called comedones, form in hair follicles due to blockage of the follicular orifice
- The clinical hallmark is the comedone, which may be closed (whitehead) or open (blackhead)
- The activity of bacteria (Propionibacterium acnes) within the comedones releases free fatty acids from sebum, causes inflammation within the cyst, and results in rupture of the cyst wall
- The first lesions, usually comedones, develop on the forehead (pre-adolescent acne)
- At its peak, acne covers the entire face (adolescent acne)
- In mature adults (25 years plus) it settles on the jaw area and the adjacent neck (adult acne).
- The scars formed after healing are often quite irregular and tend to form ‘bridges’
- Even the smaller inflamed papules can cause scars – pock-like or triangular indentations (ice-pick scars).
- Acne fulminans
- Lesions quite suddenly become very inflamed
- Affected individual is unwell and develops fever and arthralgia.
- Oral tetracycline or erythromycin.
- Topical — retinoic acid (for nodulocystic acne), benzoyl peroxide, salicylic acid.
- Sebum production is decreased by sebotrophic agents (directly) and antiandrogens (indirectly)
- Tretinoin (all trans retinoic acid)-1st generation (1G)
- Isotretinoin (13-cis isomer of tretinoin)-2G
- Adapalene — 3G
- Tazarotene — 4th generation
- Acid that is increased in acne comedones is Palmitic Acid.
- A teenager girl with moderate acne is also complaining of irregular menses. Drug of choice willl be Cyproterone Acetate.
- Oral retinoid is indicated in the treatment of Acne Vulgaris.
- A 17 year old girl with acne has been taking a drug for the last two years. She now presents with blue black pigmentation of nails. The likely medication causing the above pigmentation is: Minocycline.
- Isotretinoin is the treatment for nodulocystic acne vulgaris.
- Acne agminata also known as lupus miliaris disseminatus faciei or facial idiopathic granulomatous with regressive evolution is a disorder of uncertain etiology.It is not a variant of Acne.
- Varients of Acne,includes Acne conglobata, Acne fulminans, Pomade acne.
- Cheilitis is the most common side effect of Isotretinoin used for acne vulgaris.
- Acne Vulgaris is due to involvement of Pilosebacceous Gland.
- Adapalene is used in treatment of Acne Vulgaris.
- Causative factor for acne include Androgen, Bacterial contamination, Hypercornification of duct,Keratin,Cell nucleus.
- Only food is not a causative factor for Acne.
- Comedones are characteristics of Acne Vulgaris.
- 19 years old girl has multiple papulo pustular erythematous lesions on face and neck, the likely diagnosis is Acne Vulgaris.
- Treatment of Acne includes 13 cis retionol; Minocycline; Erytromycin; Cryotherapy; Estrogens; UV light.
- Recalcitrant Pustular Acne is treated by Retinoid.
- Minocycline is useful for inflammatory acne.
- Retinoids is useful for comedonal acne.
- A 24-year-old girl presented with complains of acne. On examination, multiple nodules, cysts and intercommunicating sinuses were seen.Oral Isotretinoin will be the treatment of choice.
- SAPHO syndrome is manifested by synovitis, acne, pustulosis, hyperostosis and osteitis.
- Difference in acne rosacea & acne vulgaris is absence of comedone.
- Testosterone hormone is responsible for acne.
Don’t Forget to Solve all the previous Year Question asked on Acne