Antimetabolites

Antimetabolites


ANTIMETABOLITES USED IN CANCER CHEMOTHERAPY

  • Compounds with structural similarity to precursors of purines or pyrimidines (Synthetic Nucleotides), or compounds that interfere with purine or pyrimidine synthesis are called antimetabolites. 

Compound

Use

Nucleoside analogue

Bromodeoxyuridinea

Study cell proliferation

Thymidine analogue

Allopurinal

Anti gout drug

Hypoxanthine analogue

Azathiopine

Immunosuppressant

Purine analogue

  • Mycophenolic Acid-Potent Reversible uncompetitive inhibitor of IMP Dehydrogenase
  • S-Fluorouracil (5FU) inhibits thymidylatesynthetase
  • Allopurinol is a powerful inhibitor of xanthine oxidase
  • Allopurinol is an analog of hypoxanthine.
Exam Question
 
  • Synthetic nucleotide used in the treatment of AIDS- Zidovudine.
  • Synthetic nucleotide used in the treatment of Gout-Allopurinol
  • Synthetic nucleotide used to suppress immunologic rejection during organ transplantation-Azathioprine.
  • Allopurinol is a powerful inhibitor of xanthine oxidase.
Don’t Forget to Solve all the previous Year Question asked on Antimetabolites

Leave a Reply

Free Mini Course on Stomach

Mini Course – Stomach

22 High Yield Topics in Stomach

in Just 2 Hours

Submission received, thank you!

Close Window
%d bloggers like this:
Malcare WordPress Security