Churg-Strauss Syndrome

Churg-Strauss Syndrome


CHURG- STRAUSS SYNDROME  (Eosinophilic Granulomatosis with Polyangiitis (EGPA)

  • Churg & Strauss is characterized by asthma, eosinophilla, extravascular granuloma formation, vasculitis.

Histophysiological features

  • A characteristic feature is eosinophilic granulomatosis with polyangitis.
  • p- ANCA is an antibody associated.

 Clinical Features-

  • Fever, malaise, anorexia, weight loss.
  • Mononeuritis multiplex is the second most common features.
  • Allergic rhinitis and sinusitis.
  • Asthma
  • Peripheral and tissue eosinophillia, extravascular necrotizing granuloma.
  • Striking eosinophilla- >1000/ cells

  Diagnosis-

  • ESR elevated
  • Α2– globulins found

 Treatment-

  • Glucocorticoids
  • In case of fail glucocorticoids treatmet, the treatment of choice is a combined of daily cyclophosphamide and prednisone.

Exam Question

 
  • Asthma ,Granuloma, Perpheral eosinophilia, Glomerulonephritis, Multisystem involvement of vessels are seen in churg- strauss syndrome 
  • Mononeuritis multiplex ,regular attacks of bronchial asthma preceded by allergic rhinitis,  cutaneous purpura with eosinophilia is suggesitve of churg- strauss syndrome 
  • Lung is characteristically involved in churg- strauss syndrome 
  • Churg Strauss Syndrome is associated with pulmonary eosinophillic pneumonia
  • Churg Strauss Syndrome is small vessels vasculitis
  • Mononeuritis multiplex is common in Churg Strauss Syndrome
  • Churg Strauss Syndrome is Often associated with Allergic Rhinitis 
  • Lower Respiratory Tract involvement  is more frequently seen in Churg Strauss Syndrome in comparison to Wegener’s Granulomatosis
Don’t Forget to Solve all the previous Year Question asked on Churg-Strauss Syndrome

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