Classification of Neoplastic Drugs

CLASSIFICATION OF NEOPLASTIC DRUGS


CLASSIFICATION OF NEOPLASTIC DRUGS

Main subdivisions Subcategories
Alkylating agents Nitrogen mustards:

  • Mechlorethamine, cyclophosphamide, ifosfamide, melphalan, chlorambucil.

Ethylenimines:

  • Thio-TEPA, hexamethylmelamine (altretamine)

Alkyl sulfonates:

  • Busulfan

Nitrosoureas:

  • Carmustine, lomustine, streptozocin.

Triazines:

  • Procarbazine, dacarbazine, temozolomide.
Platinum compounds Cisplatin, carboplatin, oxaliplatin.
Anti-metabolites Pyrimidine analogs:

  • 5-FU, cytarabine, gemcitabine

Purine analogs:

  • 6-MP, 6-thioguanine, pentostatin, cladribine

Folic acid analogs:

  • Methotrexate, pemetrexed
Natural products Vinca alkaloids:

  • Vincristine, vinblastine, vinorelbine

Taxanes:

  • Paclitaxel, docetaxel

Epipodophyllotoxins:

  • Etoposide, teniposide

Camptothecins:

  • Topotecan, irinotecan

Antitumor antibiotics:

  • Anthracyclines (daunorubicin, doxorubicin, epirubicin, idarubicin, mitoxantrone), bleomycin, dactinomycin, mitomycin-C

Enzymes: L-asparaginase

Hormones & related agents Corticosteroids:

  • Prednisolone, prednisone

Anti-estrogen drugs:

  • SERMs (tamoxifen, doloxifen) aromatase inhibitors (aminoglutethimide, formestane, exemestane, anastrozole, vorozole, letrozole)

Progestins:

  • Medroxyprogesterone acetate

Estrogens:

  • Diethylstilbesterol, ethinyl estradiol

Androgens: Testosterone

Anti-androgens: Flutamide

GnRH analogs:

  • Leuprolide, goserelin, nafarelin, buserelin, histrelin

GnRH antagonists:

  • Cetrorelix, ganirelix, abarelix
Miscellaneous agents Biological response modifiers:

  • Recombinant IL-2 (aldesleukin)
  • GM CSF(sargramostim)
  • G-CSF (filgrastim)
  • Monoclonal antibodies (rituximab, trastuzumab etc.)

Substituted urea: Hydroxyurea

Adrenal cortex suppressant: Mitotane

Tyrosine kinase inhibitors:

  • Imatinib, gefitinib, erlotinib

Retinoids: Isotretinoin

Arsenic compounds: As2 O3

Adenosine deaminase inhibitor: Pentostatin

Exam Important

CLASSIFICATION OF NEOPLASTIC DRUGS

  • Alkylating agents are subcategorized into nitrogen mustards, ethylenimines, alkyl sulfonates, nitrosoureas, triazines grp of drugs.
  • Nitrogen mustards include mechlorethamine, cyclophosphamide, ifosfamide, melphalan, chlorambucil.
  • Busulfan is an alkyl sulfonate group of drug.
  • Carmustine, lomustine, streptozocin are all nitrosoureas.
  • Triazines grp of drugs includes procarbazine, dacarbazine, temozolomide.
  • Cisplatin, carboplatin, oxaliplatin is all Platinum compounds.
  • Anti-metabolites are further divided into pyrimidine analogs, purine analogs, folic acid analogs.
  • 5-FU, cytarabine, gemcitabine are drugs included under pyrimidine analogs.
  • 6-MP, 6-thioguanine, pentostatin, cladribine are drugs included under purine analogs
  • Methotrexate is a folic acid analog.
  • Vincristine, vinblastine, vinorelbine are all Vinca alkaloids.
  • Paclitaxel, docetaxel are taxanes used as neoplastic agents.
  • Antitumor antibiotics include Anthracyclines (daunorubicin, doxorubicin, epirubicin, idarubicin, mitoxantrone), bleomycin, dactinomycin, mitomycin-C.
  • Anti-estrogen drugs like SERMs (tamoxifen, doloxifen) aromatase inhibitors (aminoglutethimide, formestane, exemestane, anastrozole, vorozole, letrozole) are all anti-neoplastic drugs.
  • Biological response modifiers include recombinant IL-2 (aldesleukin), GM CSF(sargramostim), G-CSF (filgrastim) & Monoclonal antibodies (rituximab, trastuzumab).
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