Glycolipids

GLYCOLIPIDS


GLYCOLIPIDS (GLYCOSPHINGOLIPIDS)

  • Glycosphingolipid = Sphingosine + long chain fatty acid + sugars
  • Glycolipids are synthesized in endoplasmic reticulum.
  • Glycosphingolipids are 4 types-

Cerebrosides– ( ceramide + monosaccharides)

  • Cerebroside= sphingoside + long chain fatty acid + glucose
  • Monosaccharides used is mostly glucose (glucocerebroside) or galactose (galactocerebroside).
  • Clinical Aspect- 
  1. Krabbe’s disease caused by deficiency of enzyme of ?- galactosidase (Galactocerebroside accumulates in brain).
  2. Gaucher’s disease caused by deficiency of ?- glucosidase (glucocerebrosidase)
  • Glucocerebroside (glucosylceramide) is accumulated in brain.
  1. Sulfatides– cerebroside + sulphate
  2. Globosides– ceramide + oligosaccharide
  3. Gangliosides
  • ceramide + oligosaccharide chain (glucose+galactose) + N- acetylneuromic acid (NANA)
  • Gangliosides= Sphingosine+ long chain fatty acid + oligosaccharide chain (glucose or galactose)+ NANA
  • Clinical Aspect-
  • Tay- Sach’s Disease– caused due to deficiency of hexosaminidase (alpha subunit)
  • Sandoff disease- caused due to deficiency of hexoaminidase (Beta subunit)

Exam Important

  • Glycosphingolipid = Sphingosine + long chain fatty acid + sugars
  • Glycolipids are synthesized in endoplasmic reticulum.
  • Glycosphingolipids are 4 types-

Cerebrosides– ( ceramide + monosaccharides)

  • Cerebroside= sphingoside + long chain fatty acid + glucose
  • Monosaccharides used is mostly glucose (glucocerebroside) or galactose (galactocerebroside).
  • Clinical Aspect-
  1. Krabbe’s disease caused by deficiency of enzyme of ?- galactosidase.
  2. Galactocerebroside accumulates in brain.
  3. Gaucher’s disease caused by deficiency of ?- glucosidase (glucocerebrosidase)
  4. Glucocerebroside (glucosylceramide) is accumulated in brain.
  5. Sulfatides– cerebroside + sulphate
  6. Globosides– ceramide + oligosaccharide
  7. Gangliosides
  • ceramide + oligosaccharide chain (glucose+galactose) + N- acetylneuromic acid (NANA)
  • Gangliosides= Sphingosine+ long chain fatty acid + oligosaccharide chain (glucose or galactose)+ NANA
  • Tay- Sach’s Disease– caused due to deficiency of hexosaminidase (alpha subunit) .
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