Question
All are true for this route od drug administration except ‑
| A. |
Escape first pass metabolism
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| B. |
All drugs can be given
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| C. |
Action can be terminated any time
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| D. |
Rapid absorption
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Show Answer
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Correct Answer � B
Explanation
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Ans: B.) All drugs can be given
The route of drug administration as shown in the image is the Sublingual route.
Sublingual route of administration
- The tablet or pellet containing the drug is placed under the tongue or crushed in the mouth and spread over the buccal mucosa.
- Only the lipid-soluble and non-irritating drugs can be administered by this route.
- For the sublingual route of administration, the drug should have high lipid solubility and also should be soluble in aqueous buccal fluids i.e. biphasic solubility of the drug is necessary for absorption.
- Absorption is rapid and action can be produced in minutes
- Action can be easily terminated by spitting the drug after the desired effect is achieved.
- The liver is bypassed with this route, thus the drugs with high first-pass metabolism can be easily given by this route.
- All drugs can’t be given by sublingual route.
- Drugs designed for sublingual administration, include some of the cardiovascular drugs, steroids, barbiturates, benzodiazepines, opioid analgesics with poor gastrointestinal bioavailability, enzymes and few vitamins and minerals.
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