The drug shown in the “picture below” is contraindicated in which among the following cases?
Severe heart diseases.
Severe liver diseases.
Severe kidney diseases.
All of the above.
Ans:D.)All of the above
The drug shown in the picture above is Drotaverine.
|Indication & Dosage||
As an antispasmodic
Adult: 40-80 mg tid.
Child: 1-6 yr: 20 mg 3-4 times daily; >6 yr: 40 mg tid.
|Contraindications||Severe renal/hepatic/cardiac dysfunction. Porphyria.|
|Special Precautions||Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnancy, lactation.|
|Adverse Drug Reactions||Vertigo, nausea, vomiting, dry mouth.|
|Drug Interactions||May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. The additive beneficial effect with the concurrent use of analgesics, antimuscarinics or benzodiazepines.
|Mechanism of Action||Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.|