Question
The drug shown in the “picture below” is contraindicated in which among the following cases?
| A. |
Severe heart diseases.
|
| B. |
Severe liver diseases.
|
| C. |
Severe kidney diseases.
|
| D. |
All of the above.
|
Show Answer
|
Correct Answer � D
Explanation
|
|
Ans:D.)All of the above
The drug shown in the picture above is Drotaverine.
| Indication & Dosage |
Oral
As an antispasmodic
Adult: 40-80 mg tid.
Child: 1-6 yr: 20 mg 3-4 times daily; >6 yr: 40 mg tid. |
| Contraindications |
Severe renal/hepatic/cardiac dysfunction. Porphyria. |
| Special Precautions |
Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnancy, lactation. |
| Adverse Drug Reactions |
Vertigo, nausea, vomiting, dry mouth. |
| Drug Interactions |
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. The additive beneficial effect with the concurrent use of analgesics, antimuscarinics or benzodiazepines.
|
| Mechanism of Action |
Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain. |
| CIMS Class |
Antispasmodics |
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