Question
Drug of choice in cases of overdose of drug shown in the picture below is?
| A. |
N-acetyl cysteine
|
| B. |
Protamine
|
| C. |
BAL
|
| D. |
Magnesium hydroxide gel
|
Show Answer
|
Correct Answer � A
Explanation
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|
Acetylcysteine/ N-acetylcysteine/ N-acetyl-L-cysteine/ NAC)
- It is used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose.
- N-acetylcysteine 150 mg/kg should be infused IV over 15 min, followed by the same dose IV over the next 20 hours.
- Alternatively, 75 mg/kg may be given orally every 4–6 hours for 2–3 days.
- It replenishes the glutathione stores of the liver and prevents the binding of the toxic metabolite to other cellular constituents.
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