The parasite shown in the picture above represents trematode.
Drug effective for most trematodes is Praziquantal.
o Praziquantal is the DOC for treatment of all trematodes and cestodes except for fasciola hepatica (DOC bithionol) and hydatid disease (DOC albendazole), Neurocysticercosis (DOC is albendazole).
o It acts by causing leakage of intracellular calcium from the membrane —9 contracture & paralysis.
o At relatively higher concentrations, it causes vacuolization of the tegument and release of the contents of tapeworms and flukes followed by their destruction by the host -3 this action appear to be more important in case of schistosomes and flukes.
o Despite systemic absorption praziquantel exhibits no systemic toxicity.