A 40-year-old male presented with the following lesions. Immunofluorescence shows IgG in intercellular space. What can be the most probable diagnosis?
- Pemphigus Vulgaris is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes. It is mediated by circulating autoantibodies directed against keratinocyte cell surfaces.
- Drugs reported most significantly in association with pemphigus Vulgaris include penicillamine, captopril, cephalosporin, pyrazolones, nonsteroidal anti-inflammatory drugs (NSAIDs), and other thiol-containing compounds.
- The diagnosis of pemphigus Vulgaris should be considered in any patient with persistent oral erosive lesions.
- Most patients with pemphigus Vulgaris develop cutaneous lesions. The primary lesion of pemphigus Vulgaris is a flaccid blister, which usually arises on healthy-appearing skin but may be found on erythematous skin.
Differentiating features of the major immunobullous disease