Y linked inheritance
X linked recessive inheritance
Autosomal recessive inheritance
• There is a 100% chance of all offspring developing the phenotype by inheriting the gene from an affected female parent.
• Only females will transmit the phenotype (ie, there is no male transmission of the disease).
• Males and females are equally affected by the disease.
ORGAN-BASED MITOCHONDRIAL DISEASES
• Leber hereditary optic neuropathy
• Mitochondrial myopathies (MERRF, MELAS)