Question
Identify this abnormality on pap smear:
| A. |
Normal
|
| B. |
Squamous Cell Carcinoma
|
| C. |
Adenocarcinoma
|
| D. |
High grade Squamous Intraepithelial Lesion
|
Show Answer
|
Correct Answer � D
Explanation
|
|
Ans:D.)High grade Squamous Intraepithelial Lesion.
Image shows:1 – increased number of parabasal cells, enlarged nuclei, irregular nuclear margins, expressed hyperchromia and the presence of rough chromatin deposits.
Pathology of squamous cells:
- Atypical Squamous Cells-Undetermined Significance(ASC-US)
- Atypical Squamous Cells – cannot exclude HSIL (ASC-H)
- Low grade Squamous Intraepithelial Lesions (LSIL)
- High grade Squamous Intraepithelial Lesions (HSIL)
- Squamous cell carcinoma.
| HSIL |
LSIL |
| NC ratio |
~1:2 |
~1:3 |
| Nuclear membrane irregularities |
Marked – distinct notches |
Moderate |
| Chromatin granularity |
Coarse, clumped, +/-nucleolus (red) |
Coarse, no nucleolus |
| Cytoplasmic staining |
Dark |
Light |
| Perinuclear clearing |
Usually absent |
Often present |
| Binucleation |
Uncommon |
May be present |
| Maturity of squamous cell |
Normal maturity |
Hypermature (orangeophilic cell present) |
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