Image shows:Margination of chromatin, multinucleation, cytomegaly and eosinophilic inclusions.
Herpes virus may be symptomatic and present as blisters; identical to those of the common cold sore, or it can be a dormant infection which is asymptomatic.
It is important to diagnose herpes infection as it may have adverse consequences during pregnancy. Herpes infection is known to cause encephalitis in infants.
Cytologically, the infected cells display the ‘three M’s of herpes infection’
- Margination of chromatin in the nuclei
- Moulding of nuclei
Margination of chromatin is caused by the accumulation of viral particles in the nucleus, the chromatin is no longer fine and even, but has a ground glass appearance.
Nuclear moulding is due the fact that the nuclei have outgrown the cytoplasmic area and have to sit closely together. Nuclear inclusions called ’Cowdry bodies’ can be seen