Fluid mosaic model was proposed by-
Singer and Nicolson
Meselson and Sahli
- The lipid bilayer was originally proposed by Davson and Danielle in 1935. Later, the structure of the biomembranes was described as a fluid mosaic model (Singer and Nicolson, 1972).
- The phospholipids are arranged in bilayers with the polar head groups oriented towards the extracellular side and the cytoplasmic side with a hydrophobic core.
- Each leaflet is 25 Å thick, with the head portion 10 Å and tail 15 Å thick. The total thickness is about 50 to 80 Å.
- The lipid bilayer shows the free lateral movement of its components, hence the membrane is said to be fluid in nature. Fluidity enables the membrane to perform endocytosis and exocytosis.