Question
About the following Michaelis-Menten curve, true statement is:
| A. |
Modifier can affect the catalytic site by binding to the allosteric site
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| B. |
Allosteric modifiers changes the binding constant of the enzyme but not the velocity of reaction
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| C. |
Allosteric modifier hinds in a concentration dependent manner
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| D. |
Adding more substrate to the enzyme can displace the allosteric modifier
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Show Answer
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Correct Answer � A
Explanation
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Ans: A. Modifier can affect the catalytic site by binding to the allosteric site
Ref: Harper 30/e p82, 91)
- In allosteric modification, the modifier binds to the allosteric site and changes the rate of enzymatic action at the catalytic site.
- Since it is not a type of competitive inhibition, the modifier does not bind in a concentration dependent manner and adding substrate doesn’t overcome the inhibitory effect.
- Allosteric inhibition usually decreases the velocity of the reaction without any change in Km.
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