A middle-aged lady presented to the OPD with painful blisters on the skin and oral mucosa. Direct immunofluorescence was done as shown below. All the following are true about the disease pathogenesis except?
Due to IgG against Desmoglein-1
Intercellular deposits of IgG and C3
Due to IgG against hemidesmosomes
Due to IgG against Desmoglein-3
Answer- C. Due to IgG against hemidesmosomes
- Skin as well as mucosal involvement in this patient, along with the Fishnet pattern seen in DIF points towards a diagnosis of Pemphigus Vulgaris.
- Pemphigus Vulgaris is caused by IgG antibodies against Desmoglein 1 and 3, and it is intercellular
- IgG and complement deposition in fishnet pattern IgG against hemidesmosomes and deposition in the basal layer is seen in Bullous pemphigoid.