Question
Ethylene Glycol antidote is ‑
| A. |
Barbiturates
|
| B. |
Acetylcysteine
|
| C. |
Ferric chloride
|
| D. |
Fomepizole
|
Show Answer
|
Correct Answer � D
Explanation
|
|
Ans. is ‘d’ i.e., Fomepizole
The antidote for ethylene glycol poisoning is fomepizole.
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Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. The standard treatment is inhibition of alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis.
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Fomepizole, a new inhibitor of alcohol dehydrogenase is very effective in the treatment of ethylene glycol poisoning.
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The plasma concentration of glycolate and the urinary excretion of oxalate, the major metabolites of ethylene glycol, fall after the initiation of fomepizole therapy.
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