A 40year old person presented with 10*8 swelling in a retroperitoneal, biopsy from the lesion is as shown below. Molecular analysis demonstrated t(12,16). A most probable diagnosis is
Ans: A. Myxoid liposarcoma
- Myxoid liposarcoma is the most common histologic type.
- Myxoid liposarcomas are the second-most common type of liposarcoma, representing 30–40% of all liposarcomas in the limbs, occurring most commonly in the legs, particularly the thigh, followed by the buttocks, retroperitoneum, trunk, ankle, proximal limb-girdle, head and neck, and wrist. They occur in the intermuscular fascial planes or deep-seated areas. They present as a large, slow-growing, painless mass.
- It presents the translocation at (12;16)(q13;p11)
- It is composed of monomorphic, fusiform, or stellate cells representing primitive mesenchymal cells, lying dispersed in mucopolysaccharide-rich ground substance.
- Occasional tumor giant cells may be present. The prominent meshwork of capillaries forming chicken-wire pattern is a conspicuous feature