Question
A 40year old person presented with 10*8 swelling in a retroperitoneal, biopsy from the lesion is as shown below. Molecular analysis demonstrated t(12,16). A most probable diagnosis is
| A. |
Myxoid liposarcoma
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| B. |
Lipoma
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| C. |
Synovial sarcoma
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| D. |
Pleomorphic sarcoma
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Show Answer
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Correct Answer � A
Explanation
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Ans: A. Myxoid liposarcoma
- Myxoid liposarcoma is the most common histologic type.
- Myxoid liposarcomas are the second-most common type of liposarcoma, representing 30–40% of all liposarcomas in the limbs, occurring most commonly in the legs, particularly the thigh, followed by the buttocks, retroperitoneum, trunk, ankle, proximal limb-girdle, head and neck, and wrist. They occur in the intermuscular fascial planes or deep-seated areas. They present as a large, slow-growing, painless mass.
- It presents the translocation at (12;16)(q13;p11)
- It is composed of monomorphic, fusiform, or stellate cells representing primitive mesenchymal cells, lying dispersed in mucopolysaccharide-rich ground substance.
- Occasional tumor giant cells may be present. The prominent meshwork of capillaries forming chicken-wire pattern is a conspicuous feature
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