The graph in the figure shows the serological response in resolved HBV infection, The curve to which arrow is pointing represents
Anti HbC IgG
Total Anti HbC
Anti B IgG
Ans: B.Total Anti HbC
- Anti-HBc IgG and IgM antibodies are the body’s first response to a hepatitis B virus (HBV) infection.
- These antibodies are directed against a portion of the HBV called “core”. Anti-HBc IgG and IgM appear shortly after the symptoms and onset of measurable virus surface antigen (HBsAg).
- IgM arrives first and is then replaced by IgG.
- Total Anti-HBc (IgG plus IgM) are interpreted in light of clinical factors and the results of other hepatitis B markers, particularly HBsAg and anti-HBs.
- A positive total anti-HBc result may indicate that the individual has eliminated the virus and is now immune (negative HBsAg/positive anti-HBs) or is in a recovery phase (negative HBsAg and anti-HBs / negative or positive anti-HBc IgM).
- When combined with a positive HBsAg, an active chronic infection may be suspected.
- A negative total anti-HBc result may indicate the absence of a recent or previous HBV infection (negative HBsAg and anti-HBs).