A 37-year-old man with AIDS is admitted to the hospital with a 3-week history of chest pain and shortness of breath. An X-ray film of the chest shows bilateral nodularities of the lungs. A CT-guided lung biopsy is shown in the image. The multinucleated cell in the center of this field is most likely derived from which of the following inflammatory cells?
Smooth muscle cells
- Ans D. Macrophages
- The histological picture shows granulomatous inflammation.
- Granulomas are collections of epithelioid cells and multinucleated giant cells that are formed by the cytoplasmic fusion of macrophages.
- When the nuclei are arranged around the periphery of the cell in a horseshoe pattern, the cell is termed a Langhans giant cell.
- Frequently, a foreign pathogenic agent is identified within the cytoplasm of a multinucleated giant cell, in which case the label foreign body giant cell is used. The other cells do not form multinucleated giant cells in granulomas.