A 33-year-old man with AIDS presents with multiple, purple- colored skin nodules on his hands and feet. The lesions vary in size from 1 mm to 1 cm in diameter. The biopsy of lesional skin is shown in the image. Which of the following viruses is implicated in the pathogenesis of this patient’s skin neoplasm?
Human immunodeficiency virus
- Patients with AIDS may develop Kaposi sarcoma.
- Microscopic examination of a skin lesion shows numerous poorly differentiated spindle-shaped neoplastic cells and vascular lesions filled with red blood cells, characteristic of Kaposi sarcoma.
- HHV-8 is implicated in the pathogenesis of this tumor in HIV-infected patients. HIV (choice D) by itself is not a cause of Kaposi sarcoma.