MCQ – 85516

Assertion: NPHS1 gene encodes for the protein Podocin component of podocyte foot process

Reason: podocin mutation causes a hereditary form of congenital nephrotic syndrome (Finnish type)

A.	Both assertion and reason are correct and the reason is the correct explanation of assertion.
B.	Both assertion and reason are correct and reason is not the correct explanation of assertion.
C.	Assertion is incorrect and reason is correct.
D.	Both assertion and reason are incorrect

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Correct Answer � D Explanation

• NPHS1 gene encodes for the protein Nephrin which is a component of the podocyte  foot process controlling glomerular permeability and its mutation causes a hereditary form of congenital nephrotic syndrome Finnish type.
• NPHS2 gene encodes for the protein podocin also a component of the podocyte foot process and its mutation results in the development of the steroid-resistant nephrotic syndrome of childhood-onset or autosomal recessive focal segmental glomerulosclerosis.