Assertion: Administration of ethanol is one of the treatment modalities.
Reason: Ethanol inhibits alcohol dehydrogenase.
Both assertion and reason are true, and the reason is the correct explanation for the assertion.
Both assertion and reason are true, and the reason is not the correct explanation for the assertion.
Assertion is true, but the reason is false.
Assertion is false, but the reason is true.
- Methanol is highly toxic alcohol. It is metabolized to formaldehyde (by alcohol dehydrogenase) and formic acid (by acetaldehyde dehydrogenase).
- It is the accumulation of formic acid which causes toxic effects in methanol poisoning.
- Ethanol is useful because it competitively inhibits the conversion of methanol to formic acid. Fomepizole can also be used as it is a specific inhibitor of alcohol dehydrogenase.
- Loading dose of 0.8-1 ml/kg orally of 95% ethanol (v/v) in 200 ml of orange juice or 7.6-10 ml/kg IV of 10% ethanol (v/v) in D5W over 30 min, and then maintenance dose of 0.15 ml/kg/h orally or 1.4 ml/kg/h IV. Desired serum ethanol concentration is 100-150 mg/dl.