A 22-year-old woman with leukemia undergoes bone marrow transplantation and receives a partially mismatched donor marrow. One month later, she has a scaling skin rash. The examination of a skin biopsy specimen reveals the cellular change shown in the figure. This change most likely results from which of the following biochemical reactions?
Activation of caspases
Reduction of ATP synthesis
Activation of lipases
- This cell is shrunken and has been converted into a dense eosinophilic mass.
- The surrounding cells are normal, and there is no inflammatory reaction.
- This pattern is typical of apoptosis. Caspase activation is a universal feature of apoptosis, regardless of the initiating cause.
- Apoptosis induced in recipient cells from donor lymphocytes occurs with graft-versus-host disease.
- Reduced ATP synthesis and increased glycolysis occur when a cell is subjected to anoxia. These changes are reversible.
- Lipases are activated in enzymatic fat necrosis. Lipid peroxidation occurs when the cell is injured by free radicals.