A 30-year-old man patient with severe dyspnoea. Mitral stenosis with left atrial hypertrophy is seen. Vegetations present on the mitral valve were excised. The diagnosis based on the given HPE image is most likely to be?
Rheumatic valvular disease
- Ans.C. Rheumatic valvular disease
- The given HPE image depicts Aschoff bodies, suggestive of rheumatic valvular disease.
- These myocardial inflammatory lesions are collections of lymphocytes (primarily T cells), scattered plasma cells, and plump, activated macrophages called Anitschkow cells associated with zones of fibrinoid necrosis.
- The Anitschkow cells have abundant cytoplasm and nuclei with chromatin that is centrally condensed into a slender, wavy ribbon (“caterpillar cells”).