Question
Which organism produces a potent exotoxin?
| A. |
Shigella boydii
|
| B. |
Shigella dysenteriae
|
| C. |
Shigella flexneri
|
| D. |
Shigella sonnei
|
Show Answer
|
Correct Answer � B
Explanation
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|
Ans.B. Shigella dysenteriae
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The severe diarrhoea and profound dehydration which characterize S. dysenteriae infection is due largely to the effect of a heat stable, protein exotoxin lethal to intestinal epithelial cells. Early literature described it as a “neurotoxin”.
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The other species do not produce an exotoxin but possess the common ability to penetrate epithelial cells and to release endotoxin on lysis.
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