Question
A 35-year-old woman who has a history of recurrent “corneal inflammation” developed a near full-thickness corneal ulcer. Penetrating keratoplasty was performed . Histologic examination shows a granulomatous reaction to Descemet membrane and the presence of retrocorneal tissue. What is the most likely etiologic agent for the keratitis?
| A. |
Acanthamoeba
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| B. |
Herpes virus
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| C. |
Pseudomonas
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| D. |
Candida albicans
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Show Answer
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Correct Answer � B
Explanation
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Answer: B) Herpes simplex
Explanation: A granulomatous reaction to Descemet membrane (including multinucleated giant cells) (Figs. 7-21 and 7-22) is most frequently seen with disciform keratitis with a history of herpes simplex or herpes zoster keratitis. This peculiar reaction to Descemet membrane may be related to an altered antigenicity of the membrane and subsequent development of an autosensitivity reaction. This reaction is very uncommon with other etiologic agents.
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