MCQ – 87831


A 34-year-old woman has had increasing lethargy for the past 8 months. During this time, she has experienced increased sensitivity to sunlight, and now rarely goes outdoors during the day. She has pain in her hands, elbows, knees, and feet, and muscle aches in her arms and legs. She has had increasing dyspnea for the past week. Physical examination shows no joint deformities, swelling, or redness. On auscultation of the chest, a friction rub is audible. A chest radiograph shows bilateral pleural effusions. Laboratory findings show hemoglobin, 11.6 mg/dL; hematocrit, 34.3%; MCV, 84 μm3; platelet count, 133,400/mm3; WBC count, 4610/mm3; Na+, 140 mmol/L; K+, 4 mmol/L; Cl−, 99 mmol/L; CO2, 25 mmol/L; glucose, 80 mg/dL; creatinine, 2.4 mg/dL; and calcium, 7.9 mg/dL. Which of the following additional laboratory tests would be most helpful to diagnose her underlying condition?

A. Acetylcholine receptor antibody


Antimicrosomal antibody


Antimitochondrial antibody

D. Antinuclear antibody

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