Answer : D Leishmaniasis
The condition described in question is leishmaniasis.
Leishmaniae are protozoans that are transmitted to humans through insect bites.
They cause a spectrum of clinical syndromes, ranging from indolent self-resolving cutaneous ulcers to fatal disseminated disease. Leishmaniasis is transmitted by the bite of phlebotomus sandflies, which acquire infections from feeding on infected animals.
The infestation is primarily a disease of less developed countries, where over 20 million people are believed to be infected.
Three distinct clinical entities are recognized:
(1) localized cutaneous leishmaniasis,
(3) visceral leishmaniasis.
Patients with visceral leishmaniasis suffer persistent fever, progressive weight loss, hepatosplenomegaly, anemia, thrombocytopenia, and leukopenia.
Light-skinned persons develop darkening of the skin. If untreated, the disease is fatal. Aside from clinical differences, the other choices do not represent infection of macrophages and do not lead to massive splenomegaly.