Question
A 55-year-old man from China presents with a 3-month history of scales on his skin. Physical examination reveals numerous scaly, pigmented plaques, which rub off easily. Biopsy of a plaque shows anastomosing cords of mature and stratified squamous epithelium, associated with small keratin cysts. This patient may have which of the following underlying conditions?
| A. |
Acquired immunodeficiency
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| B. |
Basal cell nevus syndrome
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| C. |
Familial hypercholesterolemia
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| D. |
Internal malignancy
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Show Answer
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Correct Answer � D
Explanation
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Correct answer : d
The condition described in the question is Seborrheic keratoses
It is scaly, frequently pigmented, elevated papules or plaques whose scales are easily rubbed off.
Microscopically, the lesions are composed of broad anastomosing cords of mature stratified squamous epithelium associated with small cysts of keratin (horn cysts).
The sudden appearance of numerous seborrheic keratoses has been associated with internal malignancies (sign of Leser-Trélat), especially gastric adenocarcinoma.
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