MCQ – 88507


A 17-year-old woman is brought to the physician by her parents because “she has been acting strangely” for a couple of days. Over the past 3 months, she has experienced malaise, joint pain, weight loss, and sporadic fever. The patient appears agitated, with a temperature of 38°C (101°F). Other physical findings include malar rash, erythematous-pink plaques with telangiectatic vessels, oral ulcers, and non blanching purpuric papules on her legs. Laboratory studies show elevated levels of BUN and creatinine. The anti–double-stranded DNA antibody The test is positive. Biopsy of sun-damaged lesional skin would most likely show which of the following histopathologic findings in this patient?

A. Acanthosis, parakeratosis, and neutrophils within the stratum corneum

B. Early dermal-epidermal separation mediated by eosinophils


Granular distribution of immune complexes in the basement membrane zone


Linear IgA deposits within dermal papillae

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